Interferons are pleiotropic cytokines that exhibit negative regulatory effects on the growth of
normal and malignant hematopoietic cells in vitro and in vivo. There are two different classes
of interferons, Type I (α, β, and ω) and Type II (γ) interferons. Although the precise
mechanisms by which these cytokines exhibit their potent effects on hematopoiesis remain
unknown, there has been considerable progress in our understanding of the cellular
changes that occur upon engagement of interferon receptors. It is now well established that …