CD4+ CD56+ hematodermic neoplasms bear a plasmacytoid dendritic cell phenotype
M Urosevic, C Conrad, J Kamarashev, K Asagoe… - Human pathology, 2005 - Elsevier
CD4+ CD56+ hematodermic neoplasms (HNs) with initial presentation in the skin are
characterized by highly aggressive behavior and poor prognosis. Recent studies indicate
that malignant cells, which are devoid of common T-, B-, NK-, and myeloid lineage markers,
may be of plasmacytoid dendritic cell (pDC) origin. We undertook a study to assess the
expression of several pDC-associated molecules on a series of 5 CD4+ CD56+ HN cases.
CD123 was expressed in all 5 cases, with some heterogeneity in individual cases. All but …
characterized by highly aggressive behavior and poor prognosis. Recent studies indicate
that malignant cells, which are devoid of common T-, B-, NK-, and myeloid lineage markers,
may be of plasmacytoid dendritic cell (pDC) origin. We undertook a study to assess the
expression of several pDC-associated molecules on a series of 5 CD4+ CD56+ HN cases.
CD123 was expressed in all 5 cases, with some heterogeneity in individual cases. All but …
