Drug-induced acute interstitial nephritis
DG Moledina, MA Perazella - … Journal of the American Society of …, 2017 - journals.lww.com
Discussion These patients illustrate two important features of DI-AIN:(1) the varied clinical
presentation, and (2) the divergent response to culprit drug discontinuation alone. The first
patient developed classic" allergic DI-AIN" with systemic and kidney manifestations,
whereas the second patient had only kidney manifestations that did not allow DI-AIN to be
easily differentiated from other causes of AKI. Furthermore, the first patient had resolution of
DI-AIN solely with drug discontinuation, whereas the second patient had worsening AKI …
presentation, and (2) the divergent response to culprit drug discontinuation alone. The first
patient developed classic" allergic DI-AIN" with systemic and kidney manifestations,
whereas the second patient had only kidney manifestations that did not allow DI-AIN to be
easily differentiated from other causes of AKI. Furthermore, the first patient had resolution of
DI-AIN solely with drug discontinuation, whereas the second patient had worsening AKI …