Gene expression profiling in kidney transplants with immune checkpoint inhibitor–associated adverse events
BA Adam, N Murakami, G Reid, K Du… - Clinical Journal of the …, 2021 - journals.lww.com
Results Significant molecular overlap was observed between immune checkpoint inhibitor–
associated acute interstitial nephritis and T cell–mediated rejection. Nevertheless, IFI27, an
IFN-α–induced transcript, was identified and validated as a novel biomarker for
differentiating immune checkpoint inhibitor–associated T cell–mediated rejection from
immune checkpoint inhibitor–associated acute interstitial nephritis (validation cohort: P<
0.001, area under the receiver operating characteristic curve= 100%, accuracy= 86%) …
associated acute interstitial nephritis and T cell–mediated rejection. Nevertheless, IFI27, an
IFN-α–induced transcript, was identified and validated as a novel biomarker for
differentiating immune checkpoint inhibitor–associated T cell–mediated rejection from
immune checkpoint inhibitor–associated acute interstitial nephritis (validation cohort: P<
0.001, area under the receiver operating characteristic curve= 100%, accuracy= 86%) …