Chemokines are instrumental in macrophage-and T cell–dependent diseases. The
chemokine CCL2 promotes kidney disease in two models of immune-mediated nephritis
(MRL-Faslpr mice and the nephrotoxic serum nephritis model), but evidence suggests that
multiple chemokines are involved. For identification of additional therapeutic targets for
immune-mediated nephritis, chemokine ligands and receptors in CCL2/and wild-type (WT)
MRL-Faslpr kidneys were profiled. The focus was on intrarenal chemokine ligand/receptor …