[PDF][PDF] Epigenetic control of NRF2-directed cellular antioxidant status in dictating life-death decisions
JD Hayes, AT Dinkova-Kostova - Molecular cell, 2017 - cell.com
Molecular cell, 2017•cell.com
In this issue of Molecular Cell, Chen et al.(2017) demonstrate that the tumor suppressor
protein ARF sensitizes cancer cells to programmed death through a surprising mechanism:
ARF physically interacts with and antagonizes activation by acetylation of the master redox
regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.
protein ARF sensitizes cancer cells to programmed death through a surprising mechanism:
ARF physically interacts with and antagonizes activation by acetylation of the master redox
regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.
In this issue of Molecular Cell, Chen et al. (2017) demonstrate that the tumor suppressor protein ARF sensitizes cancer cells to programmed death through a surprising mechanism: ARF physically interacts with and antagonizes activation by acetylation of the master redox regulator NRF2, providing an unusual mode of posttranslational NRF2 regulation.
cell.com
