[HTML][HTML] Properties of WNK1 and implications for other family members
LY Lenertz, BH Lee, X Min, B Xu, K Wedin… - Journal of Biological …, 2005 - ASBMB
WNKs are large serine/threonine protein kinases structurally distinct from all other members
of the protein kinase superfamily. Of the four human WNK family members, WNK1 and
WNK4 have been linked to a hereditary form of hypertension, pseudohypoaldosteronism
type II. We characterized the biochemical properties and regulation of WNK1 that may
contribute to its physiological activities and abnormal function in disease. We showed that
WNK1 is activated by hypertonic stress in kidney epithelial cells and in breast and colon …
of the protein kinase superfamily. Of the four human WNK family members, WNK1 and
WNK4 have been linked to a hereditary form of hypertension, pseudohypoaldosteronism
type II. We characterized the biochemical properties and regulation of WNK1 that may
contribute to its physiological activities and abnormal function in disease. We showed that
WNK1 is activated by hypertonic stress in kidney epithelial cells and in breast and colon …