[HTML][HTML] Targeted genomic deletions identify diverse enhancer functions and generate a kidney-specific, endocrine-deficient Cyp27b1 pseudo-null mouse
MB Meyer, NA Benkusky, M Kaufmann, SM Lee… - Journal of Biological …, 2019 - ASBMB
Vitamin D 3 is terminally bioactivated in the kidney to 1α, 25-dihydroxyvitamin D 3 (1, 25
(OH) 2 D 3) via cytochrome P450 family 27 subfamily B member 1 (CYP27B1), whose gene
is regulated by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1, 25
(OH) 2 D 3. Our recent genomic studies in the mouse have revealed a complex kidney-
specific enhancer module within the introns of adjacent methyltransferase-like 1 (Mettl1) and
Mettl21b that mediate basal and PTH-induced expression of Cyp27b1 and FGF23-and 1, 25 …
(OH) 2 D 3) via cytochrome P450 family 27 subfamily B member 1 (CYP27B1), whose gene
is regulated by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and 1, 25
(OH) 2 D 3. Our recent genomic studies in the mouse have revealed a complex kidney-
specific enhancer module within the introns of adjacent methyltransferase-like 1 (Mettl1) and
Mettl21b that mediate basal and PTH-induced expression of Cyp27b1 and FGF23-and 1, 25 …