The human response to acute enteral and parenteral phosphate loads
R Scanni, S Jehle, HN Hulter, R Krapf - Journal of the American …, 2014 - journals.lww.com
The human response to acute phosphate (PO4) loading is poorly characterized, and it is
unknown whether an intestinal phosphate sensor mechanism exists. Here, we characterized
the human mineral and endocrine response to parenteral and duodenal acute phosphate
loads. Healthy human participants underwent 36 hours of intravenous (IV; 1.15 [low dose]
and 2.30 [high dose] mmol of PO4/kg per 24 hours) or duodenal (1.53 mmol of PO4/kg per
24 hours) neutral sodium PO4 loading. Control experiments used equimolar NaCl loads …
unknown whether an intestinal phosphate sensor mechanism exists. Here, we characterized
the human mineral and endocrine response to parenteral and duodenal acute phosphate
loads. Healthy human participants underwent 36 hours of intravenous (IV; 1.15 [low dose]
and 2.30 [high dose] mmol of PO4/kg per 24 hours) or duodenal (1.53 mmol of PO4/kg per
24 hours) neutral sodium PO4 loading. Control experiments used equimolar NaCl loads …