Metabolic coupling factors in pancreatic β-cell signal transduction
CB Newgard, JD McGarry - Annual review of biochemistry, 1995 - annualreviews.org
CB Newgard, JD McGarry
Annual review of biochemistry, 1995•annualreviews.orgThis chapter focuses on the biochemical mechanisms that mediate glucose stimulated
insulin secretion (GSIS) from p-cells of the islets of Langerhans and the potentiating role
played by fatty acids. We summarize evidence sup porting the idea that glucose metabolism
is required for GSIS and that the GLUT-2 facilitated glucose transporter and the glucose
phosphorylating en zyme glucokinase play important roles in measuring changes in
extracellular glucose concentration. The idea that glucose metabolism is linked to insulin
insulin secretion (GSIS) from p-cells of the islets of Langerhans and the potentiating role
played by fatty acids. We summarize evidence sup porting the idea that glucose metabolism
is required for GSIS and that the GLUT-2 facilitated glucose transporter and the glucose
phosphorylating en zyme glucokinase play important roles in measuring changes in
extracellular glucose concentration. The idea that glucose metabolism is linked to insulin
Abstract
This chapter focuses on the biochemical mechanisms that mediate glucose stimulated insulin secretion (GSIS) from p-cells of the islets of Langerhans and the potentiating role played by fatty acids. We summarize evidence sup porting the idea that glucose metabolism is required for GSIS and that the GLUT-2 facilitated glucose transporter and the glucose phosphorylating en zyme glucokinase play important roles in measuring changes in extracellular glucose concentration. The idea that glucose metabolism is linked to insulin
Annual Reviews