Glycolysis, the breakdown of glucose, is one of the most conserved and extensively studied
biochemical pathways. Designing principles from chemistry and thermodynamics allow for
energy production, biosynthesis and cellular communication. However, the kinetics or
metabolic flux through the pathway also determines its function. Recently, there have been
numerous developments that establish new allosteric interactions of glycolytic enzymes with
small molecule metabolites and other mechanisms that may cooperate to allow for addition …