[HTML][HTML] Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(−)-deprenyl
E Kragten, I Lalande, K Zimmermann, S Roggo… - Journal of Biological …, 1998 - ASBMB
R-(−)-Deprenyl (Selegiline) represents one of the drugs currently used for the treatment of
Parkinson's disease. This compound was shown to protect neurons or glias from
programmed cell death in a variety of models. The mechanism of action of neuroprotection
as well as inhibition of apoptosis remains elusive. CGP 3466 is a structurally related analog
of R-(−)-deprenyl that exhibits virtually no monoamine oxidase type B inhibiting activity but is
neuroprotective in the picomolar concentration range. We showed specific binding of CGP …
Parkinson's disease. This compound was shown to protect neurons or glias from
programmed cell death in a variety of models. The mechanism of action of neuroprotection
as well as inhibition of apoptosis remains elusive. CGP 3466 is a structurally related analog
of R-(−)-deprenyl that exhibits virtually no monoamine oxidase type B inhibiting activity but is
neuroprotective in the picomolar concentration range. We showed specific binding of CGP …