[HTML][HTML] A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal …
J Richards, B Ko, S All, KY Cheng, RS Hoover… - Journal of Biological …, 2014 - ASBMB
It has been well established that blood pressure and renal function undergo circadian
fluctuations. We have demonstrated that the circadian protein Per1 regulates multiple genes
involved in sodium transport in the collecting duct of the kidney. However, the role of Per1 in
other parts of the nephron has not been investigated. The distal convoluted tubule (DCT)
plays a critical role in renal sodium reabsorption. Sodium is reabsorbed in this segment
through the actions of the NaCl co-transporter (NCC), which is regulated by the with-no …
fluctuations. We have demonstrated that the circadian protein Per1 regulates multiple genes
involved in sodium transport in the collecting duct of the kidney. However, the role of Per1 in
other parts of the nephron has not been investigated. The distal convoluted tubule (DCT)
plays a critical role in renal sodium reabsorption. Sodium is reabsorbed in this segment
through the actions of the NaCl co-transporter (NCC), which is regulated by the with-no …