Local renal circadian clocks control fluid–electrolyte homeostasis and BP
N Tokonami, D Mordasini, S Pradervand… - Journal of the …, 2014 - journals.lww.com
The circadian timing system is critically involved in the maintenance of fluid and electrolyte
balance and BP control. However, the role of peripheral circadian clocks in these
homeostatic mechanisms remains unknown. We addressed this question in a mouse model
carrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre
recombinase under the endogenous Renin promoter (Bmal1 lox/lox/Ren1 d Cre mice).
Analysis of Bmal1 lox/lox/Ren1 d Cre mice showed that the floxed Bmal1 allele was excised …
balance and BP control. However, the role of peripheral circadian clocks in these
homeostatic mechanisms remains unknown. We addressed this question in a mouse model
carrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre
recombinase under the endogenous Renin promoter (Bmal1 lox/lox/Ren1 d Cre mice).
Analysis of Bmal1 lox/lox/Ren1 d Cre mice showed that the floxed Bmal1 allele was excised …