[HTML][HTML] The effects of biological sex on sepsis treatments in animal models: a systematic review and a narrative elaboration on sex-and gender-dependent differences …
OBJECTIVES: Preclinical studies provide an opportunity to evaluate the relationship
between sex and sepsis, and investigate underlying mechanisms in a controlled
experimental environment. The objective of our systematic review was to assess the impact
of biological sex on treatment response to fluid and antibiotic therapy in animal models of
sepsis. Furthermore, we provide a narrative elaboration of sex-dependent differences in
preclinical models of sepsis. DATA SOURCES: MEDLINE and Embase were searched from …
between sex and sepsis, and investigate underlying mechanisms in a controlled
experimental environment. The objective of our systematic review was to assess the impact
of biological sex on treatment response to fluid and antibiotic therapy in animal models of
sepsis. Furthermore, we provide a narrative elaboration of sex-dependent differences in
preclinical models of sepsis. DATA SOURCES: MEDLINE and Embase were searched from …