[HTML][HTML] Genomic imprinting: CTCF protects the boundaries
The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of
the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been
shown that CTCF is also required for protection against de novo methylation of the
differentially methylated domain of H19 in the female germline.
the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been
shown that CTCF is also required for protection against de novo methylation of the
differentially methylated domain of H19 in the female germline.
Abstract
The DNA-binding protein CTCF, which acts as a chromatin ‘insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.
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