[HTML][HTML] Megakaryocyte ontogeny: clinical and molecular significance
KE Elagib, AT Brock, AN Goldfarb - Experimental hematology, 2018 - Elsevier
Highlights•Fetal megakaryocytes (Mks) are phenotypically different from adult Mks.•Fetal
Mks are matured as adult Mks.•Fetal Mk phenotypic features predispose to certain Mk-
related diseases.•Cell-intrinsic and-extrinsic factors contribute to Mk ontogenic
differences.•Fetal Mks can be established in adult mode to enhance ex vivo platelet
production.Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect
their capacity for platelet production. However, despite being smaller, more proliferative, and …
Mks are matured as adult Mks.•Fetal Mk phenotypic features predispose to certain Mk-
related diseases.•Cell-intrinsic and-extrinsic factors contribute to Mk ontogenic
differences.•Fetal Mks can be established in adult mode to enhance ex vivo platelet
production.Fetal megakaryocytes (Mks) differ from adult Mks in key parameters that affect
their capacity for platelet production. However, despite being smaller, more proliferative, and …
