Physiologic frailty in nonelderly hematopoietic cell transplantation patients: results from the bone marrow transplant survivor study

M Arora, CL Sun, KK Ness, JB Teh, J Wu… - JAMA …, 2016 - jamanetwork.com
Importance Frailty results in decreased physiological reserve and diminished resistance to
stressors; approximately 10% of those in the elderly population (those≥ 65 years) are frail.
High-intensity treatments and complications after hematopoietic cell transplantation (HCT)
injure normal tissues and may increase the risk of frailty even among nongeriatric HCT
patients. Objective To determine the prevalence of frailty in young adult HCT patients (18-to
64-year-olds) and siblings; and the impact of frailty on subsequent mortality in HCT …