[HTML][HTML] Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression
DC Newcomb, U Sajjan, S Nanua, Y Jia… - Journal of Biological …, 2005 - ASBMB
Rhinovirus (RV) is a common cause of asthma exacerbations. The signaling mechanisms
regulating RV-induced airway epithelial cell responses have not been well studied. We
examined the role of phosphatidylinositol (PI) 3-kinase in RV-induced interleukin (IL)-8
expression. Infection of 16HBE14o-human bronchial epithelial cells with RV39 induced
rapid activation of PI 3-kinase and phosphorylation of Akt, a downstream effector of PI 3-
kinase. RV39 also colocalized with cit-Akt-PH, a citrogen-tagged fluorescent fusion protein …
regulating RV-induced airway epithelial cell responses have not been well studied. We
examined the role of phosphatidylinositol (PI) 3-kinase in RV-induced interleukin (IL)-8
expression. Infection of 16HBE14o-human bronchial epithelial cells with RV39 induced
rapid activation of PI 3-kinase and phosphorylation of Akt, a downstream effector of PI 3-
kinase. RV39 also colocalized with cit-Akt-PH, a citrogen-tagged fluorescent fusion protein …