Rett syndrome and epilepsy: an update for child neurologists
A Dolce, B Ben-Zeev, S Naidu, EH Kossoff - Pediatric neurology, 2013 - Elsevier
Rett syndrome, a neurogenetic disorder predominantly affecting females, has many
characteristic features including psychomotor retardation, impaired language development,
hand stereotypies, gait dysfunction, and acquired microcephaly. Although each of these
features undoubtedly contributes to the morbidity of this neurologic disorder, epilepsy is
perhaps one of the most well-described and problematic, affecting as many as 50%-90% of
patients. Seizures can often be refractory, requiring polytherapy and consideration of …
characteristic features including psychomotor retardation, impaired language development,
hand stereotypies, gait dysfunction, and acquired microcephaly. Although each of these
features undoubtedly contributes to the morbidity of this neurologic disorder, epilepsy is
perhaps one of the most well-described and problematic, affecting as many as 50%-90% of
patients. Seizures can often be refractory, requiring polytherapy and consideration of …
