Multicenter prospective study of concordance between embryonic cell-free DNA and trophectoderm biopsies from 1301 human blastocysts

C Rubio, L Navarro-Sánchez… - American journal of …, 2020 - Elsevier
Background The recent identification of embryonic cell-free DNA in spent blastocyst media
has opened a new era of possibilities for noninvasive embryo aneuploidy testing in assisted
reproductive technologies. Yet, previous studies assessing a limited number of embryos
reported variable concordance between embryonic cell-free DNA and trophectoderm
biopsies, thus questioning the validity of this approach. Objective This study aimed to
evaluate the concordance and reproducibility of testing embryonic cell-free DNA vs …