[HTML][HTML] Pushing the limits of detection: investigation of cell-free DNA for aneuploidy screening in embryos
JR Ho, N Arrach, K Rhodes-Long, A Ahmady, S Ingles… - Fertility and sterility, 2018 - Elsevier
Objective To determine the accuracy of cell-free DNA (cfDNA) in spent embryo medium
(SEM) for ploidy and sex detection at the cleavage and blastocyst stages. To determine if
assisted hatching (AH) and morphologic grade influence cfDNA concentration and accuracy.
Design Prospective cohort. Setting Academic fertility center. Patient (s) Nine patients
undergoing IVF; 41 donated two-pronuclei embryos and 20 embryos from patients
undergoing preimplantation genetic testing for aneuploidy (PGT-A). Interventions (s) In a …
(SEM) for ploidy and sex detection at the cleavage and blastocyst stages. To determine if
assisted hatching (AH) and morphologic grade influence cfDNA concentration and accuracy.
Design Prospective cohort. Setting Academic fertility center. Patient (s) Nine patients
undergoing IVF; 41 donated two-pronuclei embryos and 20 embryos from patients
undergoing preimplantation genetic testing for aneuploidy (PGT-A). Interventions (s) In a …