[HTML][HTML] Embryonic cell-free DNA versus trophectoderm biopsy for aneuploidy testing: concordance rate and clinical implications
C Rubio, L Rienzi, L Navarro-Sánchez, D Cimadomo… - Fertility and sterility, 2019 - Elsevier
Objective To study whether embryonic cell-free DNA (cfDNA) in spent blastocyst media is
representative of the chromosomal constitution of a blastocyst. Design Pilot prospective
blinded study. Setting In vitro fertilization center and genetics laboratory. Patient (s) A total of
115 trophectoderm (TE) biopsies and spent blastocyst media (SBM) from 46 patients with
ages ranging from 32 to 46 years, whose indications for preimplantation genetic testing of
aneuploidy (PGT-A) were advanced maternal age, recurrent miscarriage, or recurrent …
representative of the chromosomal constitution of a blastocyst. Design Pilot prospective
blinded study. Setting In vitro fertilization center and genetics laboratory. Patient (s) A total of
115 trophectoderm (TE) biopsies and spent blastocyst media (SBM) from 46 patients with
ages ranging from 32 to 46 years, whose indications for preimplantation genetic testing of
aneuploidy (PGT-A) were advanced maternal age, recurrent miscarriage, or recurrent …