[HTML][HTML] Structural and immunological characterization of recombinant 6-cysteine domains of the Plasmodium falciparum sexual stage protein Pfs230
NJ MacDonald, V Nguyen, R Shimp, K Reiter… - Journal of Biological …, 2016 - ASBMB
Development of a Plasmodium falciparum (Pf) transmission blocking vaccine (TBV) has the
potential to significantly impact malaria control. Antibodies elicited against sexual stage
proteins in the human bloodstream are taken up with the blood meal of the mosquitoes and
inactivate parasite development in the mosquito. In a phase 1 trial, a leading TBV identified
as Pfs25-EPA/Alhydrogel® appeared safe and immunogenic, however, the level of Pfs25-
specific antibodies were likely too low for an effective vaccine. Pfs230, a 230-kDa sexual …
potential to significantly impact malaria control. Antibodies elicited against sexual stage
proteins in the human bloodstream are taken up with the blood meal of the mosquitoes and
inactivate parasite development in the mosquito. In a phase 1 trial, a leading TBV identified
as Pfs25-EPA/Alhydrogel® appeared safe and immunogenic, however, the level of Pfs25-
specific antibodies were likely too low for an effective vaccine. Pfs230, a 230-kDa sexual …