A surface protein expressed during the transformation of zygotes of Plasmodium gallinaceum is a target of transmission-blocking antibodies
CA Grotendorst, N Kumar, R Carter… - Infection and …, 1984 - Am Soc Microbiol
CA Grotendorst, N Kumar, R Carter, DC Kaushal
Infection and immunity, 1984•Am Soc MicrobiolAntibodies against gametes of malarial parasites (Plasmodium spp.) have previously been
shown to block infectivity of the parasites to mosquitoes by preventing fertilization of the
parasites in the insect midgut. These antibodies did not have any effect on the development
of fertilized parasites. We now report that a surface protein of Mr 26,000 synthesized by
zygotes of P. gallinaceum is the target of antibodies which block infectivity of the fertilized
parasites to mosquitoes. Identification of this target antigen offers a new stage of the parasite …
shown to block infectivity of the parasites to mosquitoes by preventing fertilization of the
parasites in the insect midgut. These antibodies did not have any effect on the development
of fertilized parasites. We now report that a surface protein of Mr 26,000 synthesized by
zygotes of P. gallinaceum is the target of antibodies which block infectivity of the fertilized
parasites to mosquitoes. Identification of this target antigen offers a new stage of the parasite …
Antibodies against gametes of malarial parasites (Plasmodium spp.) have previously been shown to block infectivity of the parasites to mosquitoes by preventing fertilization of the parasites in the insect midgut. These antibodies did not have any effect on the development of fertilized parasites. We now report that a surface protein of Mr 26,000 synthesized by zygotes of P. gallinaceum is the target of antibodies which block infectivity of the fertilized parasites to mosquitoes. Identification of this target antigen offers a new stage of the parasite against which a malaria transmission-blocking vaccine could be developed.
American Society for Microbiology