IL-17 inhibits osteoblast differentiation and bone regeneration in rat
Abstract Objective The interleukin-17 (IL-17) family is a group of pro-inflammatory cytokines
that are produced by a subset of helper T cells. IL-17 family members are not only involved
in the immune response of tissues but also play a role in bone metabolism. Although the role
of IL-17 in osteoclast-mediated bone resorption has been extensively studied, its role during
osteoblast-mediated bone formation has rarely been investigated. In this study, we
examined the effect of IL-17 on osteogenesis in rats both in vitro and in vivo. Design To …
that are produced by a subset of helper T cells. IL-17 family members are not only involved
in the immune response of tissues but also play a role in bone metabolism. Although the role
of IL-17 in osteoclast-mediated bone resorption has been extensively studied, its role during
osteoblast-mediated bone formation has rarely been investigated. In this study, we
examined the effect of IL-17 on osteogenesis in rats both in vitro and in vivo. Design To …
