RGM co-receptors add complexity to BMP signaling
TD Mueller - Nature structural & molecular biology, 2015 - nature.com
TD Mueller
Nature structural & molecular biology, 2015•nature.comTen years ago, the repulsive guidance molecules (RGMs), a family of three
glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-
receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures
provide exciting insights into how RGM co-receptors may modulate BMP signaling.
glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-
receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures
provide exciting insights into how RGM co-receptors may modulate BMP signaling.
Ten years ago, the repulsive guidance molecules (RGMs), a family of three glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures provide exciting insights into how RGM co-receptors may modulate BMP signaling.
nature.com