Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation
R Schoenfeld, A Wong, J Silva, M Li, A Itoh, M Horiuchi… - Mitochondrion, 2010 - Elsevier
Demyelination occurs in multiple inherited mitochondrial diseases. We studied which genes
were induced as a consequence of differentiation in rodent and human oligodendroglia.
Cholesterol, myelin and mitochondrial genes were significantly increased with
oligodendroglial differentiation. Mitochondrial DNA content per cell and acetyl CoA-related
transcripts increased significantly; thus, the large buildup of cholesterol necessary for
myelination appears to require mitochondrial production of acetyl-CoA. Oligodendroglia …
were induced as a consequence of differentiation in rodent and human oligodendroglia.
Cholesterol, myelin and mitochondrial genes were significantly increased with
oligodendroglial differentiation. Mitochondrial DNA content per cell and acetyl CoA-related
transcripts increased significantly; thus, the large buildup of cholesterol necessary for
myelination appears to require mitochondrial production of acetyl-CoA. Oligodendroglia …
