Severe compromise of preosteoblasts in a surgical mouse model of bisphosphonate-associated osteonecrosis of the jaw
LA Córdova, F Guilbaud, J Amiaud, S Battaglia… - Journal of Cranio …, 2016 - Elsevier
Objectives The effect of amino-bisphosphonates on osteoblastic lineage and its potential
contribution to the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw
(BONJ) remain controversial. We assessed the effects of zoledronic acid (ZOL) on bone and
vascular cells of the alveolar socket using a mouse model of BONJ. Material and methods
Thirty-two mice were treated twice a week with either 100 μg/kg of ZOL or saline for 12
weeks. The first left maxillary molar was extracted at the third week. Alveolar sockets were …
contribution to the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw
(BONJ) remain controversial. We assessed the effects of zoledronic acid (ZOL) on bone and
vascular cells of the alveolar socket using a mouse model of BONJ. Material and methods
Thirty-two mice were treated twice a week with either 100 μg/kg of ZOL or saline for 12
weeks. The first left maxillary molar was extracted at the third week. Alveolar sockets were …