Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro
EC Patin, S Willcocks, S Orr, TH Ward… - Innate …, 2016 - journals.sagepub.com
EC Patin, S Willcocks, S Orr, TH Ward, R Lang, UE Schaible
Innate immunity, 2016•journals.sagepub.comThe role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has
not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-
dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-
regulation of IL-12p40 secretion. Thus, Mincle mediates both pro-as well as anti-
inflammatory responses.
not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-
dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-
regulation of IL-12p40 secretion. Thus, Mincle mediates both pro-as well as anti-
inflammatory responses.
The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion. Thus, Mincle mediates both pro- as well as anti-inflammatory responses.
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