Inducible nitric oxide synthase activation by interleukin-17
D Miljkovic, V Trajkovic - Cytokine & growth factor reviews, 2004 - Elsevier
Interleukin-17 (IL-17) is a proinflammatory T cell cytokine presumably involved in
physiological responses to infection, but also in immunopathology of autoimmune disorders
such as rheumatoid arthritis. The proinflammatory action of IL-17 depends considerably on
its ability to trigger the expression of inducible nitric oxide (NO) synthase (iNOS), an enzyme
responsible for the generation of cytotoxic and immunoregulatory free radical NO. Here we
discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze …
physiological responses to infection, but also in immunopathology of autoimmune disorders
such as rheumatoid arthritis. The proinflammatory action of IL-17 depends considerably on
its ability to trigger the expression of inducible nitric oxide (NO) synthase (iNOS), an enzyme
responsible for the generation of cytotoxic and immunoregulatory free radical NO. Here we
discuss the role of IL-17 in the cytokine network controlling iNOS expression, and analyze …
