[HTML][HTML] A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system
I Inoue, A Rohrwasser, C Helin, X Jeunemaitre… - Journal of Biological …, 1995 - ASBMB
Angiotensinogen exhibits genetic linkage to and association with essential hypertension
and preeclampsia, a common hypertensive disorder of pregnancy; however, the
polymorphisms detected thus far provide no functional clues. In a preeclamptic patient, we
have identified a mutation leading to the replacement of leucine by phenylalanine at position
10 of mature angiotensinogen (L10F), the site of renin cleavage. Kinetic analyses of the
enzymes of the renin-angiotensin system, using either model peptides or full-length …
and preeclampsia, a common hypertensive disorder of pregnancy; however, the
polymorphisms detected thus far provide no functional clues. In a preeclamptic patient, we
have identified a mutation leading to the replacement of leucine by phenylalanine at position
10 of mature angiotensinogen (L10F), the site of renin cleavage. Kinetic analyses of the
enzymes of the renin-angiotensin system, using either model peptides or full-length …