Efficient Liver-specific Deletion of a Floxed Human Angiotensinogen Transgene by Adenoviral Delivery of Cre Recombinasein Vivo
DE Stec, RL Davisson, RE Haskell, BL Davidson… - Journal of Biological …, 1999 - ASBMB
Tissue-specific ablation of gene function is possible in vivo by the Cre-loxP recombinase
system. We generated transgenic mice containing a human angiotensinogen gene flanked
by loxP sites (hAGT flox). To examine the physiologic consequences of tissue-specific loss
of angiotensinogen gene function in vivo, we constructed an adenovirus expressing Cre
recombinase. Studies were performed in several independent lines of hAGT flox mice before
and after intravenous administration of either Adcre or AdβGal as a control. Systemic …
system. We generated transgenic mice containing a human angiotensinogen gene flanked
by loxP sites (hAGT flox). To examine the physiologic consequences of tissue-specific loss
of angiotensinogen gene function in vivo, we constructed an adenovirus expressing Cre
recombinase. Studies were performed in several independent lines of hAGT flox mice before
and after intravenous administration of either Adcre or AdβGal as a control. Systemic …
