γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis
Highlights•HITS-CLIP and PAR-CLIP provide putative target lists for KSHV and EBV
miRNAs.•Both KSHV and EBV mimic host cellular miRNAs in lymphoid and endothelial
cells.•EBV and KSHV miRNAs regulate B cell proliferation and contribute to tumorigenesis.•
Although with different sequences γ-herpesvirus miRNAs target common cellular
pathways.To date, more than 200 viral miRNAs have been identified mostly from
herpesviruses and this rapidly evolving field has recently been summarized in a number of …
miRNAs.•Both KSHV and EBV mimic host cellular miRNAs in lymphoid and endothelial
cells.•EBV and KSHV miRNAs regulate B cell proliferation and contribute to tumorigenesis.•
Although with different sequences γ-herpesvirus miRNAs target common cellular
pathways.To date, more than 200 viral miRNAs have been identified mostly from
herpesviruses and this rapidly evolving field has recently been summarized in a number of …