[HTML][HTML] Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction
Metformin, a well known antidiabetic agent that improves peripheral insulin sensitivity, also
elicits anti-inflammatory actions, but its mechanism is unclear. Here, we investigated the
mechanism responsible for the anti-inflammatory effect of metformin action in
lipopolysaccharide (LPS)-stimulated murine macrophages. Metformin inhibited LPS-induced
production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in a concentration-
dependent manner and in parallel induction of activating transcription factor-3 (ATF-3), a …
elicits anti-inflammatory actions, but its mechanism is unclear. Here, we investigated the
mechanism responsible for the anti-inflammatory effect of metformin action in
lipopolysaccharide (LPS)-stimulated murine macrophages. Metformin inhibited LPS-induced
production of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in a concentration-
dependent manner and in parallel induction of activating transcription factor-3 (ATF-3), a …