Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life

JM Bertho, C Demarquay, N Moulian… - Cellular …, 1997 - Elsevier
We analyzed cellular content of thymic samples from 26 human healthy donors, ranging
from 1 week postnatal to 49 years old. Our results showed that there was an overall
decrease in cellular density, beginning early during life, but with two peaks of cellular
density, at 9 months and 10 years of age. Histological and immunohistological analyses
showed that variations in cellular density were correlated with the morphological changes
observed during thymic involution, namely the enlargement of interlobular trabeculae and …