[HTML][HTML] The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and …
B McCright, AM Rivers, S Audlin, DM Virshup - Journal of Biological …, 1996 - ASBMB
Protein phosphatase 2A is a heterotrimeric protein serine/threonine phosphatase consisting
of a 36-kDa catalytic C subunit, a 65-kDa structural A subunit, and a variable regulatory B
subunit. The B subunits determine the substrate specificity of the enzyme. There have been
three families of cellular B subunits identified to date: B55, B56 (B′), and PR72/130. We
have now cloned five genes encoding human B56 isoforms. Polypeptides encoded by all
but one splice variant (B56γ1) are phosphoproteins, as shown by mobility shift after …
of a 36-kDa catalytic C subunit, a 65-kDa structural A subunit, and a variable regulatory B
subunit. The B subunits determine the substrate specificity of the enzyme. There have been
three families of cellular B subunits identified to date: B55, B56 (B′), and PR72/130. We
have now cloned five genes encoding human B56 isoforms. Polypeptides encoded by all
but one splice variant (B56γ1) are phosphoproteins, as shown by mobility shift after …