Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38α mitogen-activated protein kinase pathway during ischemia-reperfusion …
X Zhang, P Shan, J Alam, RJ Davis, RA Flavell… - Journal of Biological …, 2003 - ASBMB
Carbon monoxide is protective in ischemia-reperfusion organ injury, but the precise
mechanisms remain elusive. We have recently shown that low levels of exogenous carbon
monoxide (CO) utilize p38 MAPK and attenuate caspase 3 activity to exert an antiapoptotic
effect during lung ischemia-reperfusion injury. Our current data demonstrate that CO
activates the p38α MAPK isoform and the upstream MAPK kinase MKK3 to modulate
Fas/Fas ligand expression; caspases 3, 8, and 9; mitochondrial cytochrome c release; Bcl-2 …
mechanisms remain elusive. We have recently shown that low levels of exogenous carbon
monoxide (CO) utilize p38 MAPK and attenuate caspase 3 activity to exert an antiapoptotic
effect during lung ischemia-reperfusion injury. Our current data demonstrate that CO
activates the p38α MAPK isoform and the upstream MAPK kinase MKK3 to modulate
Fas/Fas ligand expression; caspases 3, 8, and 9; mitochondrial cytochrome c release; Bcl-2 …
