[HTML][HTML] Serotonergic 5-HT2B receptor controls tissue-nonspecific alkaline phosphatase activity in osteoblasts via eicosanoids and phosphatidylinositol-specific …
A Baudry, J Bitard, S Mouillet-Richard, M Locker… - Journal of biological …, 2010 - ASBMB
In previous studies, we observed that mice knocked out for the serotonin-2B receptor (5-HT
2B R) show defects in bone homeostasis. The present work focuses on the downstream
targets relaying the anabolic function of this receptor in osteoblasts. A functional link
between the 5-HT 2B R and the activity of the tissue-nonspecific alkaline phosphatase
(TNAP) is established using the C1 osteoprogenitor cell line. During C1 osteogenic
differentiation, both 5-HT 2B R and TNAP mRNA translations are delayed with respect to …
2B R) show defects in bone homeostasis. The present work focuses on the downstream
targets relaying the anabolic function of this receptor in osteoblasts. A functional link
between the 5-HT 2B R and the activity of the tissue-nonspecific alkaline phosphatase
(TNAP) is established using the C1 osteoprogenitor cell line. During C1 osteogenic
differentiation, both 5-HT 2B R and TNAP mRNA translations are delayed with respect to …