Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer
KC Arden - Experimental gerontology, 2006 - Elsevier
The FOXO family of transcription factors has been implicated in several cellular processes
including cell cycle arrest, cell death and protection from stress stimuli. FOXO function is
influenced by multiple signaling pathways. Many of these pathways are known to be
misregulated in cancer. Perturbation of FOXO function leads to uncontrolled cell proliferation
and accumulation of DNA damage. It is becoming clear that active FOXO proteins play an
important role in keeping cells in check and inactivation of FOXO proteins is associated with …
including cell cycle arrest, cell death and protection from stress stimuli. FOXO function is
influenced by multiple signaling pathways. Many of these pathways are known to be
misregulated in cancer. Perturbation of FOXO function leads to uncontrolled cell proliferation
and accumulation of DNA damage. It is becoming clear that active FOXO proteins play an
important role in keeping cells in check and inactivation of FOXO proteins is associated with …